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One thing that patients and healthcare providers want to make sure of is that bone or joint pain aren't related to a cancer recurrence. Maintaining good communication and letting your healthcare team know what kinds of pain you're having will help them sort out whether this is an anticipated side effect of treatment or whether it's something that deserves a little more evaluation. In patients who received Neupogen—which is a white blood cell growth factor— during chemotherapy, we have noted that bone pain is a common complaint, but that it does tend to get better over time. For patients who are currently on Neupogen, the pain can be quite severe. Sometimes the best treatment is to reduce the dose while making sure the white blood cell counts are still in a good range.